An ionised/non-ionised dual porosity model of intervertebral disc tissue
نویسندگان
چکیده
منابع مشابه
An ionised/non-ionised dual porosity model of intervertebral disc tissue.
The volume of the intrafibrillar water space--i.e. the water contained inside the collagen fibres--is a key parameter that is relevant to concepts of connective tissue structure and function. Confined compression and swelling experiments on annulus fibrosus samples are interpreted in terms of a dual porosity model that distinguishes between a non-ionised intrafibrillar porosity and an ionised e...
متن کاملMechanobiological Models for Intervertebral Disc Tissue Engineering
Low back pain, which is often caused by disc degeneration, is a major health problem. Due to the limitations of the current treatments for degenerative disc disease, tissue engineering methods have been proposed. These methods present the opportunity to restore the functionality of the intervertebral disc by repairing or replacing the degenerated tissue. One of the major challenges in intervert...
متن کاملGenetic and Functional Studies of the Intervertebral Disc: A Novel Murine Intervertebral Disc Model
Intervertebral disc (IVD) homeostasis is mediated through a combination of micro-environmental and biomechanical factors, all of which are subject to genetic influences. The aim of this study is to develop and characterize a genetically tractable, ex vivo organ culture model that can be used to further elucidate mechanisms of intervertebral disc disease. Specifically, we demonstrate that IVD di...
متن کاملSingle Voxel Spectroscopy Of Intervertebral Disc Degeneration — An In Vitro Bovine Disc Degeneration Model
Introduction: Intervertebral Disc Disease (IVDD) afflicts nearly 12 million people in the United States and is a leading cause of lumbar spine-related lowerback pain [1]. Conventional magnetic resonance imaging (MRI) has a critical role in detection of late-stage degenerative changes (such as changes in disc morphology, height, bulge and herniation). Recently, other MRI methods have been propos...
متن کاملDual - Porosity Reservoir Model with an Improved Coupling Term
A new dual-porosity model is developed for singlephase flow in fractured/porous media. As in the commonly-used approach, flow is assumed to take place through the fracture network, and between the fractures and matrix blocks. The matrix blocks are treated in a lumped-parameter manner, with a single average pressure used for each matrix block. However, instead of assuming that fracture/matrix fl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biomechanics and Modeling in Mechanobiology
سال: 2003
ISSN: 1617-7959,1617-7940
DOI: 10.1007/s10237-002-0023-y